Lipretto
Total Skin Perfector
"The Poetry of Youth,
Written by the Symphony of Science."
A WORLD FIRST: Botox-like effect (Vamtoxin™) and Retinoic Acid-like renewal (Retinogin™) combined in a single dual-peptide complex for the first time.
Lipretto is a hybrid innovation redefining 'gold standards' in dermocosmetics, simultaneously intervening in dynamic and static wrinkles. Experience the world's first dual-action peptide technology for serene, line-free skin and youthful cellular rebirth.
Dual-Action Technology
Two Peptides, One Solution — Why Lipretto?
VAMTOXIN™
Topical Botulinum Effect
Targets dynamic wrinkles by inhibiting SNARE complex formation. Softens muscle movements similar to Botox, reducing forehead lines, crow's feet, and frown lines.
-61.6% SNARE Complex Inhibition
SYNERGISTIC ACTION
The Lipretto Advantage
Lipretto™ attacks both faces of aging simultaneously. Dynamic wrinkles from muscle movement AND static wrinkles from tissue loss — addressed in one formula.
Complete Anti-Aging Solution
RETINOGIN™
Re-Surfacing Technology
Targets static wrinkles through TGF-β pathway activation. Repairs tissue loss with irritant-free retinoid power — no redness, no peeling, available 24/7.
163% Collagen Synthesis Increase
500 Da
Ultra-low molecular weight for maximum skin penetration
Non-Invasive
Needle-free alternative to injectable treatments
Biomimetic
Direct cell receptor stimulation, zero antigenicity risk
The Science Behind Lipretto
Dual-Peptide Technology: Scientific Excellence & Clinical Evidence
VAMTOXIN™ — Topical Botulinum Effect
The 'Peptide Neurotoxin' Revolution in Dynamic Wrinkles
The Problem: Expression Lines
When expressing emotions, facial expressions change. Facial expression changes occur due to the contraction and relaxation of facial muscles, resulting in wrinkles such as forehead lines, frown lines, crow's feet, and smile lines, known as 'Expression Lines'.
In young skin, 'Expression Lines' appear temporarily and disappear when the face is relaxed. However, aged skin loses elasticity, and even when the face is relaxed, 'Expression Lines' persist.
SNARE Complex Inhibition
- •Target Proteins: Targets VAMP2 and SNAP-25 proteins to trigger their degradation
- •ACh Blockage: Prevents excessive muscle contraction by inhibiting Acetylcholine (ACh) release
- •Result: Immediate and cumulative relaxation of mimic lines, crow's feet, glabellar
Similar mechanism to Botox, but topical and non-invasive
500 Dalton Advantage
Ultra-low molecular weight enables stratum corneum penetration to target tissue
No Injections
Ideal for patients with injection phobia or seeking to extend Botox effects
Precision
Synthetic structure ensures no antigenicity risk from cell receptors
Clinical Evidence
VAMTOXIN inhibits SNARE Complex formation by 61.6%
28.3% reduction in wrinkle depth after 5 hours
RETINOGIN™ — The Future of Re-Surfacing Technology
The Power of 'Irritant-Free Retinoid' in Cellular Renewal
The Problem: Retinol Burn
Traditional retinoid-based products cause severe side effects known as 'Retinol Burn' — redness, stinging sensation, peeling of the skin, and sometimes intense pain.
- • High likelihood of photosensitivity reactions from UV exposure
- • Only recommended for night use
- • Easily oxidized by light and heat
The Solution: RETINOGIN™ Peptide
Overcoming the limitations of retinol with breakthrough peptide technology:
Matrix Stimulation via TGF-β Pathway
- 1.Stimulates the skin's natural growth factors (e.g., TGF-β)
- 2.Increases synthesis of Collagen I, III, IV and Hyaluronic Acid
- 3.Restructures the skin 'from the inside out' without peeling
Key Difference: Unlike retinol which causes surface peeling, RETINOGIN works at the cellular level through RAR (Retinoic Acid Receptor) activation.
Clinical Evidence
163% collagen synthesis vs 34% for retinol
33.5% under-eye wrinkle reduction in 4 weeks
The Lipretto Difference
Lipretto Product
Total Skin Perfector — The Most Powerful Instrument in Your Prescription
Lipretto
Total Skin Perfector
Experience the world's first dual-action peptide for serene, line-free skin and a youthful cellular rebirth. Combining Vamtoxin™ and Retinogin™ in one powerful formula.
Botox-like effect for dynamic wrinkles
Retinoid-like renewal without irritation
Ultra-low molecular weight for maximum penetration
Recommended Usage:
WT% : 1~5% (Final peptide concentration in formula 5~25ppm)
Preservative-Free
2-year shelf life with excellent structural stability under harsh conditions
Patented Formula
Active ingredients developed by SupadElixir Co., Ltd.
Professional Grade
Designed for aesthetic clinics and dermatological practice
Peptide Technical Specifications
VAMTOXIN™ Solution 500-W
| Product Name | VAMTOXIN™ Solution 500-W |
| Molecular Weight | ~500 Da |
| Concentration | 0.05% VAMTOXIN™ Peptide |
| Function | Expression lines & wrinkle improvement |
RETINOGIN™ Solution 400-W
| Product Name | RETINOGIN™ Solution 400-W |
| Molecular Weight | ~500 Da |
| Concentration | 0.04% RETINOGIN™ Peptide |
| Function | Firmness, skin tone & regenerative cycle |
Clinical Application Areas
Synergy and Results — Professional Treatment Solutions
Post-Botox/Filler Support
Extends treatment permanence and duration. Enhances and prolongs the effects of injectable procedures for sustained results.
- •Increases treatment longevity
- •Optimizes injection results
- •Reduces frequency of touch-ups
Anti-Aging for Sensitive Skin
The "Gold Standard" for patients without retinoid tolerance. Perfect for those who cannot use traditional retinol-based products.
- •Zero irritation formula
- •Safe for reactive skin types
- •Day and night application
Pre-Post Operative Care
Optimizes surgical results by improving skin quality. Enhances dermatological procedure outcomes before and after treatments.
- •Improves skin quality pre-surgery
- •Accelerates post-procedure healing
- •Maximizes treatment outcomes
Lipretto is where molecular biology meets aesthetics. We are offering our patients not just a cream, but an engineering marvel that works at the cellular level.
Doctor's Opinion
Clinical Dermatology Perspective
Dynamic + Static wrinkles in one formula
Designed for aesthetic clinics
Clinical evidence & in-vivo studies
Zero irritation, biomimetic precision
Experience the Lipretto Revolution
Join leading dermatologists and aesthetic professionals worldwide who trust Lipretto for breakthrough dual-peptide anti-aging treatment